CCAAT/Enhancer-binding protein homologous protein (CHOP) decreases bone formation and causes osteopenia
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چکیده
منابع مشابه
CCAAT/enhancer-binding protein homologous protein (CHOP) regulates osteoblast differentiation.
Differentiation of committed osteoblasts is controlled by complex activities involving signal transduction and gene expression, and Runx2 and Osterix function as master regulators for this process. Recently, CCAAT/enhancer-binding proteins (C/EBPs) have been reported to regulate osteogenesis in addition to adipogenesis. However, the roles of C/EBP transcription factors in the control of osteobl...
متن کاملMisexpression of CCAAT/enhancer binding protein beta causes osteopenia.
CCAAT/enhancer binding proteins (C/EBPs) are expressed by osteoblasts and adipocytes during differentiation. C/EBP beta is critical for adipogenesis; however, its role in osteoblastogenesis is unclear, and its function in the postnatal skeleton is not known. To study C/EBP beta in osteoblasts in vivo, we created transgenic mice expressing full length C/EBP beta under the control of a 3.8 kb fra...
متن کاملRegulation of CCAAT/Enhancer-binding Protein Homologous Protein (CHOP) Expression by Interleukin-1 in Pancreatic Cells*
Apoptosis contributes to immune-mediated pancreatic cell destruction in type I diabetes. Exposure of cells to interleukin-1 (IL-1 ) causes endoplasmic reticulum stress and activates proapoptotic networks. Here, we show that nuclear factor B (NFB) and mitogen-activated protein kinase (MAPK) signaling pathways regulate the expression of CCAAT/enhancer-binding protein homologous protein (CHOP), wh...
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BACKGROUND AND AIMS C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism. To explore the role of CHOP in hepatocarcinogenesis, we induced hepatocellular carcinoma (HCC) in wild type (wt) and CHOP knockout (KO) mice using the carcinogen N-diethyln...
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http://bloodjournal.hematologylibrary.org/content/104/13/3911.full.html Updated information and services can be found at: (3094 articles) Hematopoiesis and Stem Cells (1086 articles) Gene Expression Articles on similar topics can be found in the following Blood collections http://bloodjournal.hematologylibrary.org/site/misc/rights.xhtml#repub_requests Information about reproducing this ar...
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ژورنال
عنوان ژورنال: Bone
سال: 2007
ISSN: 8756-3282
DOI: 10.1016/j.bone.2006.09.028